Mortality in sickle cell anemia in Africa: a prospective cohort study in Tanzania

Autor: Albert Komba, David J. Roberts, Stella Rwezaula, Jesse Kitundu, Fenella J. Kirkham, Kevin Marsh, Hadija Mwamtemi, Brett Lowe, Julie Oruo, Charles R. Newton, Gregory Fegan, Thomas N. Williams, Kisali Pallangyo, Pius Magesa, Elineema Meda, Sharon E. Cox, Deogratius Soka, Josephine Mgaya, David Muturi, Julie Makani
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Pediatrics
lcsh:Medicine
Tanzania
Cohort Studies
0302 clinical medicine
Risk Factors
PNEUMOCOCCAL PROPHYLAXIS
BLOOD-TRANSFUSION
NATURAL-HISTORY
DISEASE
CHILDREN
SURVIVAL
DEATH
DISORDERS
MORBIDITY
JAMAICA
Cause of Death
Medicine
Prospective Studies
030212 general & internal medicine
lcsh:Science
Child
Prospective cohort study
Cause of death
Genetics and Genomics/Medical Genetics
education.field_of_study
Multidisciplinary
Incidence
Mortality rate
Public Health and Epidemiology/Global Health
Middle Aged
3. Good health
Child
Preschool
030220 oncology & carcinogenesis
Cohort
Female
Research Article
Cohort study
Adult
medicine.medical_specialty
Adolescent
Anemia
Population
Anemia
Sickle Cell
Young Adult
03 medical and health sciences
Humans
education
business.industry
Public health
lcsh:R
Infant
Newborn
Infant
medicine.disease
Africa
lcsh:Q
Hematology/Hemoglobinopathies
business
Follow-Up Studies
Zdroj: PLoS ONE
PLOS ONE, 6 (2), Article e14699. (2011)
PLoS ONE, Vol 6, Iss 2, p e14699 (2011)
ISSN: 1932-6203
Popis: Background:The World Health Organization has declared Sickle Cell Anemia (SCA) a public health priority. There are 300,000 births/year, over 75% in Africa, with estimates suggesting that 6 million Africans will be living with SCA if average survival reaches half the African norm. Countries such as United States of America and United Kingdom have reduced SCA mortality from 3 to 0.13 per 100 person years of observation (PYO), with interventions such as newborn screening, prevention of infections and comprehensive care, but implementation of interventions in African countries has been hindered by lack of locally appropriate information. The objective of this study was to determine the incidence and factors associated with death from SCA in Dar-es-Salaam.Methods and Findings:A hospital-based cohort study was conducted, with prospective surveillance of 1,725 SCA patients recruited from 2004 to 2009, with 209 (12%) lost to follow up, while 86 died. The mortality rate was 1.9 (95%CI 1.5, 2.9) per 100 PYO, highest under 5-years old [7.3 (4.8-11.0)], adjusting for dates of birth and study enrollment. Independent risk factors, at enrollment to the cohort, predicting death were low hemoglobin (
Databáze: OpenAIRE
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