Pediatric Clostridioides difficile Infection: Diagnosis and Diagnostic Stewardship
| Autor: | Nira R. Pollock, Ana M Vaughan-Malloy, Hayden T. Schwenk |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
genetic structures Clostridioides difficile business.industry Bacterial Toxins General Medicine Infection diagnosis Disease Feces Infectious Diseases Bacterial Proteins Clostridioides Pediatrics Perinatology and Child Health Toxin detection Clostridium Infections Humans Medicine Nucleic Acid Amplification Tests Test performance Enzyme immunoassays Stewardship Child business Intensive care medicine |
| Zdroj: | Journal of the Pediatric Infectious Diseases Society. 10:S16-S21 |
| ISSN: | 2048-7207 |
| Popis: | Although the pathogenesis of Clostridioides difficile infection (CDI) is complex and incompletely understood, it is believed that the elaboration of C. difficile toxins is necessary for disease. There are a variety of tests available for the detection of both the C. difficile organism and its toxins; however, each has limitations and the best application of these tests to the diagnosis of CDI in children remains uncertain. Nucleic acid amplification tests are unable to reliably discriminate between CDI and C. difficile colonization, while commercially available enzyme immunoassays for toxin detection lack sensitivity. An understanding of preanalytic factors, relevant patient features, and test performance characteristics is essential to the accurate diagnosis of CDI in children. Specific diagnostic stewardship strategies can also increase the likelihood that positive tests reflect disease rather than colonization. Ultimately, CDI remains a clinical diagnosis and clinical judgment is essential when interpreting test results, regardless of the methods used. |
| Databáze: | OpenAIRE |
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