High Throughput Screening for Bioactive Components from Traditional Chinese Medicine
| Autor: | Yan-hui Zhu, Zhiyun Zhang, Dale E. Mais, Ming-Wei Wang, Meng Zhang |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Biological Products
Plants Medicinal Emerging technologies Computer science Drug discovery High-throughput screening Organic Chemistry Drug Evaluation Preclinical General Medicine Traditional Chinese medicine Data science Combinatorial chemistry High-Throughput Screening Assays Computer Science Applications Resource (project management) Drug Discovery Screening method Animals Humans Medicine Chinese Traditional Drugs Chinese Herbal Biological evaluation |
| Zdroj: | Combinatorial Chemistry & High Throughput Screening. 13:837-848 |
| ISSN: | 1386-2073 |
| Popis: | Throughout the centuries, traditional Chinese medicine has been a rich resource in the development of new drugs. Modern drug discovery, which relies increasingly on automated high throughput screening and quick hit-to-lead development, however, is confronted with the challenges of the chemical complexity associated with natural products. New technologies for biological screening as well as library building are in great demand in order to meet the requirements. Here we review the developments in these techniques under the perspective of their applicability in natural product drug discovery. Methods in library building, component characterizing, biological evaluation, and other screening methods including NMR and X-ray diffraction are discussed. |
| Databáze: | OpenAIRE |
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