Synthesis of C11-Desmethoxy Soraphen A1α: A Natural Product Analogue That Inhibits Acetyl-CoA Carboxylase

Autor:	Daniel P. Canterbury, Kristen E.N. Scott, Glenn C. Micalizio, Rolf Jansen, John L. Cleveland, Ozora Kubo
Rok vydání:	2013
Předmět:	chemistry.chemical_compound Natural product chemistry Stereochemistry Organic Chemistry Drug Discovery Acetyl-CoA carboxylase Soraphen A Biology Biochemistry Polyketide synthesis Pyruvate carboxylase
Zdroj:	ACS Medicinal Chemistry Letters. 4:1244-1248
ISSN:	1948-5875
Popis:	A synthesis of C11-desmethoxy soraphen A1α is described that proceeds in just 14 steps from readily available starting materials. This natural product analogue was identified as a target of interest in a program aimed at identifying novel natural product-inspired inhibitors of acetyl-CoA carboxylase (ACC) as potential anticancer therapeutics. While describing the most efficient synthesis of a soraphen A1α analogue (total syntheses of the natural product have been reported that proceed in 25 to ≥40 linear steps), we also present data supporting the conclusion that C11-heteroatom functionality is a beneficial but unnecessary structural characteristic of soraphen A1α analogues for inhibiting ACC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8f8ed256182b8b15efe3726a5ff8f7 https://doi.org/10.1021/ml400377p Zobrazit plný text záznamu