Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection
| Autor: | Nico Ghilardi, Andrea M. Cooper, Santiago Partida-Sanchez, Shabaana A. Khader, Guy K. Bell, Susan L. Swain, Frederic Desauvage, Frances E. Lund, Dawn M. Jelley-Gibbs, John E. Pearl |
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| Rok vydání: | 2006 |
| Předmět: |
CD4-Positive T-Lymphocytes
T cell Immunology Priming (immunology) chemical and pharmacologic phenomena Biology Lymphocyte Activation Article Mycobacterium tuberculosis Mice 03 medical and health sciences 0302 clinical medicine Cell Movement In vivo medicine Animals Immunology and Allergy Dendritic cell migration Tuberculosis Pulmonary Lymph node Cells Cultured 030304 developmental biology Mice Knockout 0303 health sciences Interleukin-12 Subunit p40 Interleukin hemic and immune systems Articles Dendritic Cells biology.organism_classification Interleukin-12 3. Good health Mice Inbred C57BL Protein Subunits medicine.anatomical_structure Interleukin 12 Lymph Nodes 030215 immunology |
| Zdroj: | The Journal of Experimental Medicine |
| ISSN: | 1540-9538 0022-1007 |
| DOI: | 10.1084/jem.20052545 |
| Popis: | Migration of dendritic cells (DCs) to the draining lymph node (DLN) is required for the activation of naive T cells. We show here that migration of DCs from the lung to the DLN after Mycobacterium tuberculosis (Mtb) exposure is defective in mice lacking interleukin (IL)-12p40. This defect compromises the ability of IL-12p40–deficient DCs to activate naive T cells in vivo; however, DCs that express IL-12p40 alone can activate naive T cells. Treatment of IL-12p40–deficient DCs with IL-12p40 homodimer (IL-12(p40)2) restores Mtb-induced DC migration and the ability of IL-12p40–deficient DCs to activate naive T cells. These data define a novel and fundamental role for IL-12p40 in the pathogen-induced activation of pulmonary DCs. |
| Databáze: | OpenAIRE |
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