Integrin-Mediated Targeted Cancer Therapy Using c(RGDyK)-Based Conjugates of Gemcitabine

Autor:	Theodora Chatzisideri, George Leonidis, Theodoros Karampelas, Eleni Skavatsou, Angeliki Velentza-Almpani, Francesca Bianchini, Constantin Tamvakopoulos, Vasiliki Sarli
Rok vydání:	2021
Předmět:	Antimetabolites Antineoplastic Integrins Lung Neoplasms Deoxycytidine Peptides Cyclic Gemcitabine Mice Inbred C57BL Mice A549 Cells Integrin c(RGDyK)-based conjugates gemcitabine Targeted Cancer Therapy Drug Discovery Animals Humans Molecular Medicine Cell Proliferation
Zdroj:	Journal of Medicinal Chemistry. 65:271-284
ISSN:	1520-4804 0022-2623
Popis:	c(RGDyK)-based conjugates of gemcitabine (GEM) with the carbonate and carbamate linkages in the 6-OH group of GEM were synthesized for the targeted delivery of GEM to integrin α
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce8d9bbffe24b7eefa8283c50b24c88a https://doi.org/10.1021/acs.jmedchem.1c01468 Zobrazit plný text záznamu