Plasticity of the interface between oxytocin neurons and the vasculature in late pregnant rats: An ultrastructural morphometric study
| Autor: | Enrique J. Blanco, Gustav F. Jirikowski, Ricardo Vázquez, Christoph Pilgrim |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
medicine.medical_specialty
Histology Lateral hypothalamus Ovariectomy Immunocytochemistry Biology Oxytocin Pregnancy Internal medicine Lactation medicine Animals Neurons Basement membrane Microcirculation Brain Rats Inbred Strains Cell Biology General Medicine Immunohistochemistry Rats Microscopy Electron Apposition medicine.anatomical_structure Endocrinology nervous system Hypothalamus Ovariectomized rat Pregnancy Animal Female medicine.drug |
| Zdroj: | Acta Histochemica. 91:165-172 |
| ISSN: | 0065-1281 |
| DOI: | 10.1016/s0065-1281(11)80272-2 |
| Popis: | Summary Increased numbers of oxytocin-immunoreactive perivascular neurons have been shown to occur in thepreoptic region and lateral hypothalamus of female rats around parturition. In the present study, electron microscopical immunocytochemistry and morphometry were used to examine such perivascular oxytocinergic neurons as well as those in the classical magnocellular nuclei in late pregnant and lactating rats. In 22 d pregnant animals and in rats killed after 2 d of lactation, numerous oxytocinergic neurons were found in direct apposition to the outer basement membrane of arterioles, venules, and capillaries. The distance between immunoreactive neurons and blood vessels was significantly lower in these animals than in 9 d lactating rats and in ovariectomized controls. It is likely that, around parturition, oxytocinergic perivascular neurons are uncovered by active retraction of glial elements. This plasticity is perhaps facilitated by changing hormonal conditions around parturition. The observed changes seem to be transitory and might reflect altered secretory properties of perivascular oxytocinergic neurons. |
| Databáze: | OpenAIRE |
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