Calcium-ATPase and insulin in adolescent offspring of essential hypertensive parents
| Autor: | María Gimenez, M. Romo, L. Rabinovich, B Grunfeld, R Simsolo |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Adolescent medicine.medical_treatment Radioimmunoassay Calcium-Transporting ATPases Essential hypertension Excretion Child of Impaired Parents Internal medicine Internal Medicine medicine Humans Insulin Child Calcium metabolism Glucose tolerance test medicine.diagnostic_test business.industry Spectrophotometry Atomic Area under the curve Glucose Tolerance Test medicine.disease Urinary calcium Calcium ATPase Endocrinology Cholesterol Data Interpretation Statistical Hypertension Calcium Female business |
| Zdroj: | Hypertension (Dallas, Tex. : 1979). 26(6 Pt 2) |
| ISSN: | 0194-911X |
| Popis: | Abstract A number of abnormalities in calcium homeostasis have been reported in patients with essential hypertension. In turn, insulin has been shown to influence the activity of the Ca 2+ -ATPase. We have previously shown that normotensive offspring of essential hypertensive individuals have an exaggerated insulin response to a glucose overload. Therefore, the aim of the present study was to evaluate basal and calmodulin-activated Ca 2+ -ATPase in red blood cells and its relationship to the insulin response during an intravenous glucose tolerance test in 27 normotensive adolescents with a family history of essential hypertension (F+) (mean age, 13.9±0.5 years) and in 10 control subjects matched for age and body mass index with no family history of hypertension (F−). The results (mean±SD) were as follows (μmol Pi/[mg protein/h]10 −1 ): basal Ca 2+ -ATPase, 4.5±1.2 in F+ and 5.1±1.6 in F− ( P =NS); calmodulin-activated Ca 2+ -ATPase, 13.6±3.9 in F+ and 16.2±1.7 in F− ( P P =NS). Calmodulin-activated Ca 2+ -ATPase showed a negative correlation with the insulin area under the curve ( r =−.59, P r =−.38, P P =NS). Our findings indicate a diminished activity of calmodulin-stimulated Ca 2+ -ATPase despite increased levels of insulin, a known activator of this pump, further suggesting the presence of insulin resistance in normotensive offspring of essential hypertensive individuals. Since Ca 2+ -ATPase is an extrusion pump, a drop in its activity may lead to an increase in intracellular calcium accumulation and thus contribute to the development of hypertension. |
| Databáze: | OpenAIRE |
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