ABCC8 mRNA expression is an independent prognostic factor for glioma and can predict chemosensitivity
Autor: | Zheng Zhao, Yanwei Liu, Rui-Chao Chai, Yinyuan Wang, Tao Jiang, Kaijia Zhou, Guanzhang Li, Lijie Huang |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
Adult
Male Prognostic factor medicine.medical_treatment Mrna expression lcsh:Medicine Sulfonylurea Receptors Article ABCC8 Medical research Glioma Biomarkers Tumor Temozolomide medicine Humans lcsh:Science Chemotherapy Messenger RNA Multidisciplinary Molecular medicine biology Brain Neoplasms business.industry Single factor lcsh:R Prognosis medicine.disease Survival Analysis Isocitrate Dehydrogenase Up-Regulation Gene Expression Regulation Neoplastic Neurology Mutation biology.protein Cancer research Female lcsh:Q Chromosome Deletion Neoplasm Grading business Biomarkers medicine.drug |
Zdroj: | Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) Scientific Reports |
ISSN: | 2045-2322 |
Popis: | Glioma is the most common primary intracranial tumor and is associated with very low survival rates. The development of reliable biomarkers can help to elucidate the molecular mechanisms involved in glioma development. Here the expression of ABCC8 mRNA, clinical characteristics, and survival information based on 1893 glioma samples from four independent databases were analyzed. The expression patterns of ABCC8 mRNA were compared by a Chi square test. The overall survival rate of gliomas was evaluated according to the expression level of ABCC8 mRNA. The prognostic value of this marker in gliomas was tested using Cox single factor and multi factor regression analyses. We found patients with low WHO grade, oligodendrocytoma, low molecular grade, IDH mutation, and 1p19q combined deletion had high ABCC8 mRNA expression. The patients with high expression of ABCC8 mRNA had longer survival. ABCC8 mRNA expression was a new independent prognostic index for glioma. Temozolomide chemotherapy was an independent index to prolong overall survival in high ABCC8 mRNA expression glioma patients, whereas in patients with low expression, there was no significant difference. So ABCC8 mRNA expression could be an independent prognostic indicator for glioma patients and could predict the sensitivity of glioma to temozolomide. |
Databáze: | OpenAIRE |
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