Recognition motif and mechanism of ripening inhibitory peptides in plant hormone receptor ETR1
| Autor: | Georg Groth, Anna Kinnen, Holger Gohlke, Markus Dick, Daniel Mulnaes, Christopher Pfleger, Dalibor Milić |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Ethylene Receptors Peptide Amino Acid Motifs Arabidopsis lcsh:Medicine Peptide Receptors Cell Surface Plasma protein binding 01 natural sciences Article 03 medical and health sciences chemistry.chemical_compound Plant Growth Regulators Gene Expression Regulation Plant 0103 physical sciences Receptor lcsh:Science Plant Proteins chemistry.chemical_classification Peptide Metabolism Multidisciplinary 010304 chemical physics biology Arabidopsis Proteins lcsh:R food and beverages Ripening Ethylenes biology.organism_classification Plants Genetically Modified Cell biology 030104 developmental biology chemistry Fruit ddc:000 lcsh:Q Plant hormone Signal transduction Peptides ethylene signaling ethylene receptor ripening inhibition Protein Binding Signal Transduction |
| Zdroj: | Scientific reports 8(1), 3890 (2018). doi:10.1038/s41598-018-21952-3 Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018) |
| DOI: | 10.1038/s41598-018-21952-3 |
| Popis: | Synthetic peptides derived from ethylene-insensitive protein 2 (EIN2), a central regulator of ethylene signalling, were recently shown to delay fruit ripening by interrupting protein–protein interactions in the ethylene signalling pathway. Here, we show that the inhibitory peptide NOP-1 binds to the GAF domain of ETR1 – the prototype of the plant ethylene receptor family. Site-directed mutagenesis and computational studies reveal the peptide interaction site and a plausible molecular mechanism for the ripening inhibition. |
| Databáze: | OpenAIRE |
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