Cell surface receptors in lysophospholipid signaling
| Autor: | Jerold Chun, Brigitte Anliker |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Sphingosine
Morphogenesis Cell Biology Biology Cell biology Mice Receptors Lysosphingolipid chemistry.chemical_compound Phenotype chemistry Cell surface receptor Lysophosphatidic acid Animals lipids (amino acids peptides and proteins) Sphingosine-1-phosphate Lysophospholipids Receptors Lysophosphatidic Acid Signal transduction Receptor Signal Transduction Developmental Biology G protein-coupled receptor |
| Zdroj: | Seminars in Cell & Developmental Biology. 15:457-465 |
| ISSN: | 1084-9521 |
| DOI: | 10.1016/j.semcdb.2004.05.005 |
| Popis: | The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), regulate various signaling pathways within cells by binding to multiple G protein-coupled receptors. Receptor-mediated LPA and S1P signaling induces diverse cellular responses including proliferation, adhesion, migration, morphogenesis, differentiation and survival. This review will focus on major components of lysophospholipid signaling: metabolism, identification and expression of LPA and S1P receptors, general signaling pathways and specific signaling mechanisms in mouse embryonic fibroblasts. Finally, in vivo effects of LP receptor gene deletion in mice will be discussed. |
| Databáze: | OpenAIRE |
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