N-Methyl-d-aspartate (NMDA) receptor antibody in relation to autism spectrum disorder (ASD): presence and association with symptom profile
| Autor: | Ghada Refaat Amin Taha, Mohammad Abdullah Ahmad Abdullah Elshiekh, Reem El Ghamry, Heba H. Elshahawi, Hanan Azzam, Ahmed Adel Mohammad Abdelgawad |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Autism
Population RC435-571 medicine.disease_cause mental disorders Medicine education Autoantibodies Autoimmune encephalitis Psychiatry education.field_of_study biology business.industry Research Autoantibody Immune dysregulation medicine.disease NMDA receptor Psychiatry and Mental health nervous system Autism spectrum disorder Immunology biology.protein Antibody business Autoimmune |
| Zdroj: | Middle East Current Psychiatry Middle East Current Psychiatry, Vol 28, Iss 1, Pp 1-8 (2021) |
| ISSN: | 2090-5416 |
| Popis: | Background Several studies pointed to immune dysregulation abnormalities linked to autism spectrum disorders (ASD). Of those, several autoantibodies had been identified. Recent findings of N-methyl d-aspartate (NMDA) antibodies in autoimmune encephalitis suggested that it caused symptoms like autistic regression. Thus, the purpose of the study was to test for the presence of anti-NMDAR antibodies in the ASD disorder population and to correlate this with the clinical findings. Results Eighty-seven autistic children, 4–12 years old, were enrolled in the study and were matched with sixty typically developing children used as controls. The diagnosis of cases was confirmed by ADOS-2 and clinical evaluation. None of the control children had positive anti-NMDAR antibodies, while 26.4% (23 children) of the patients’ group were positive for serum anti-NMDA receptor antibodies (> 200 pg/ml, p = 0.0157). The positive anti-NMDAR antibody was statistically correlated with better speech stage (p = 0.017), more severe stereotyped behavior (p ≤ 0.001), and abnormal EEG findings (p = 0.025). Conclusions There is a possibility of the presence of anti-NMDAR antibodies in the autism spectrum disorder population with certain characteristics, especially the severity of the stereotyped behaviors. |
| Databáze: | OpenAIRE |
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