IL-1β and IL-8, matrix metalloproteinase 3, and pepsinogen secretion before and afterH. pylorieradication in gastroduodenal phenotypes
| Autor: | Hyo Jong Kim, Kwang Ro Joo, Seok Ho Dong, Young Woon Chang, Hyo Jung Lee, Sung-Soo Kim, Byung Ho Kim, Young Hwangbo, Jaewon Lee, Jae Young Jang, Rin Chang, Hyoung-Chul Oh |
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| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Matrix Metalloproteinase 3 medicine.medical_specialty Atrophic gastritis Spirillaceae Interleukin-1beta Gastroenterology Helicobacter Infections Pepsin Pepsinogen A Internal medicine Genotype medicine Humans Korea Polymorphism Genetic Helicobacter pylori biology business.industry Interleukin-8 Radioimmunoassay Middle Aged biology.organism_classification medicine.disease digestive system diseases Phenotype Haplotypes Gastric Mucosa Case-Control Studies Immunology biology.protein Female Gastritis medicine.symptom business |
| Zdroj: | Scandinavian Journal of Gastroenterology. 43:1184-1193 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.1080/00365520802130209 |
| Popis: | Relations between host genetic factors and clinical outcomes of Helicobacter pylori infection are variable among ethnicities. The aim of this study was to examine gastric mucosal cytokines, matrix metalloproteinase 3 (MMP-3), and serum pepsinogen levels before and after eradication of H. pylori according to IL-1B genotypes and benign gastroduodenal phenotypes in a Korean population.A total of 349 Koreans including H. pylori-infected subjects (n=230) and H. pylori-negative controls (n=119) were enrolled. The former subjects were classified into groups according to the presence of non-atrophic gastritis (n=74), atrophic gastritis (n=56), gastric ulcer (n=37), and duodenal ulcer (n=63). IL-1B polymorphisms were genotyped by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Gastric mucosal IL-1beta, IL-8, and MMP-3, and serum pepsinogen I and II levels were measured by ELISA and radioimmunoassay, respectively.There were no significant differences between the IL-1B-31/-511 haplotype (TT/CC, CT/CT, and CC/TT) frequencies among the H. pylori-positive and -negative groups. The genotypes of IL-1B-31/-511 polymorphisms did not affect clinical phenotypes, inflammatory cytokines, MMP-3, and pepsinogen secretion. Subjects with H. pylori-infected atrophic gastritis exhibited significantly higher basal levels of cytokines and a lower pepsinogen I/II ratio than those of other groups. Following H. pylori eradication, inflammatory cytokines significantly decreased and the pepsinogen I/II ratio increased in all groups.Mucosal inflammatory cytokines, MMP-3, and pepsinogen secretion are related to gastroduodenal phenotypes but not to IL-1B genotypes. Eradication of H. pylori can reduce mucosal inflammation and restore pepsinogen secretion. |
| Databáze: | OpenAIRE |
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