Non-transferrin-bound iron is associated with biomarkers of oxidative stress, inflammation and endothelial dysfunction in type 2 diabetes

Autor: A. John Moody, Desley White, Husam Aljwaid, Jonathan Pinkney, Keith J. Collard
Rok vydání: 2015
Předmět:
Male
Endocrinology
Diabetes and Metabolism
Type 2 diabetes
Endocrinology
Reference Values
Malondialdehyde
Endothelial dysfunction
chemistry.chemical_classification
biology
medicine.diagnostic_test
Middle Aged
Prognosis
C-Reactive Protein
Serum iron
Transferrins
Female
E-Selectin
Adult
medicine.medical_specialty
Iron
Enzyme-Linked Immunosorbent Assay
Risk Assessment
Statistics
Nonparametric
Predictive Value of Tests
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Obesity
Soluble transferrin receptor
Aged
Glycated Hemoglobin
Inflammation
Analysis of Variance
Transferrin saturation
business.industry
C-reactive protein
medicine.disease
Oxidative Stress
Cross-Sectional Studies
chemistry
Diabetes Mellitus
Type 2
Transferrin
biology.protein
Endothelium
Vascular
business
Biomarkers
Diabetic Angiopathies
Zdroj: Journal of diabetes and its complications. 29(7)
ISSN: 1873-460X
Popis: To investigate the association between circulating non-transferrin-bound iron [NTBI], and markers of oxidative stress, endothelial function and inflammation in subjects with type 2 diabetes and non-diabetic subjects with varying degrees of obesity.Plasma NTBI was measured by HPLC, together with total iron, iron-binding capacity, transferrin saturation and soluble transferrin receptor, together with total and reduced ascorbate, malondialdehyde [MDA], E-selectin and high-sensitivity c-reactive protein [hs-CRP] in groups of 28 subjects with type 2 diabetes, 28 non-obese controls and 17 obese non-diabetic subjects.Levels of NTBI were higher than controls in the diabetes group, but the total serum iron levels were lower. MDA levels were higher than controls in both the diabetes and obese groups, and this was associated with higher levels of oxidised ascorbate. hs-CRP levels were higher in both the diabetes and obese groups, and E-selectin was significantly higher in the diabetes group. There were strong positive correlations between HbA1c levels and NTBI [P0.01], HbA1c and E-selectin [P0.001] and NTBI and E-selectin [P0.02] in the diabetes group.These results support the hypothesis that iron-mediated oxidative stress may be a mechanism linking poor glycaemic control with vascular dysfunction in type 2 diabetes.
Databáze: OpenAIRE
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