A voxel‐based asymmetry study of the relationship between hemispheric asymmetry and language dominance in Wada tested patients
| Autor: | Vanessa Sluming, Anthony G Marson, U. C. Wieshmann, Andrew R. Mayes, Gus A. Baker, Paul Eldridge, Simon S. Keller, Neil Roberts, Enis Cezayirli |
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| Přispěvatelé: | University of St Andrews. School of Medicine, University of St Andrews. Education Division |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Insula Functional Laterality Superior temporal gyrus 0302 clinical medicine cerebral asymmetry Brain asymmetry Language lateralization Research Articles Language Cerebral Cortex Radiological and Ultrasound Technology medicine.diagnostic_test language lateralization 05 social sciences Electroencephalography Anatomy Middle Aged Magnetic Resonance Imaging Neurology Cerebral asymmetry Wada test Female RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry Research Article Adult BF Psychology NDAS BF Neuroimaging insula 050105 experimental psychology Temporal lobe 03 medical and health sciences Inferior temporal gyrus Broca's area medicine Journal Article Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Epilepsy business.industry nervous system RC0321 Orbitofrontal cortex Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Human Brain Mapping Keller, S S, Roberts, N, Baker, G, Sluming, V, Cezayirli, E, Mayes, A, Eldridge, P, Marson, A G & Wieshmann, U C 2018, ' A voxel-based asymmetry study of the relationship between hemispheric asymmetry and language dominance in Wada tested patients ', Human Brain Mapping . https://doi.org/10.1002/hbm.24058 |
| ISSN: | 1097-0193 1065-9471 |
| Popis: | SSK was supported by a UK Medical Research Council grant (grant number MR/K023152/1). Determining the anatomical basis of hemispheric language dominance (HLD) remains an important scientific endeavor. The Wada test remains the gold standard test for HLD and provides a unique opportunity to determine the relationship between HLD and hemispheric structural asymmetries on MRI. In this study, we applied a whole‐brain voxel‐based asymmetry (VBA) approach to determine the relationship between interhemispheric structural asymmetries and HLD in a large consecutive sample of Wada tested patients. Of 135 patients, 114 (84.4%) had left HLD, 10 (7.4%) right HLD, and 11 (8.2%) bilateral language representation. Fifty‐four controls were also studied. Right‐handed controls and right‐handed patients with left HLD had comparable structural brain asymmetries in cortical, subcortical, and cerebellar regions that have previously been documented in healthy people. However, these patients and controls differed in structural asymmetry of the mesial temporal lobe and a circumscribed region in the superior temporal gyrus, suggesting that only asymmetries of these regions were due to brain alterations caused by epilepsy. Additional comparisons between patients with left and right HLD, matched for type and location of epilepsy, revealed that structural asymmetries of insula, pars triangularis, inferior temporal gyrus, orbitofrontal cortex, ventral temporo‐occipital cortex, mesial somatosensory cortex, and mesial cerebellum were significantly associated with the side of HLD. Patients with right HLD and bilateral language representation were significantly less right‐handed. These results suggest that structural asymmetries of an insular‐fronto‐temporal network may be related to HLD. Publisher PDF |
| Databáze: | OpenAIRE |
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