Analysis and modelling of cholesterol and high-density lipoprotein cholesterol changes across the range of C-reactive protein levels in clinical practice as an aid to better understanding of inflammation–lipid interactions
| Autor: | Allan Cameron, Naveed Sattar, Hanna Johnsson, Maurizio Panarelli |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Immunology Population Inflammation Disease Models Biological Statistics Nonparametric General Biochemistry Genetics and Molecular Biology Arthritis Rheumatoid chemistry.chemical_compound High-density lipoprotein Rheumatology Risk Factors Humans Immunology and Allergy Medicine Least-Squares Analysis education Aged Retrospective Studies education.field_of_study biology business.industry Cholesterol Cholesterol HDL C-reactive protein Confounding Middle Aged C-Reactive Protein Nonlinear Dynamics chemistry Cardiovascular Diseases biology.protein Female lipids (amino acids peptides and proteins) medicine.symptom business Lipoprotein |
| Zdroj: | Annals of the Rheumatic Diseases. 73:1495-1499 |
| ISSN: | 1468-2060 0003-4967 |
| Popis: | Raised total cholesterol (TC) and reduced high-density lipoprotein (HDL) cholesterol levels are established cardiovascular disease (CVD) risk factors. However, in autoimmune conditions the lipid-CVD association appears paradoxical, with inflammation as a potential confounding factor. We therefore sought to model the relationship between systemic inflammatory illness and lipid levels using C-reactive protein (CRP) as the prototypical marker of inflammation. Our hypothesis was that there would be an inverse association between raised CRP levels and both TC and HDL-cholesterol levels.Results from samples analysed simultaneously for CRP and lipids in a 6-month period were collected retrospectively from a large city hospital laboratory database that collates results from both primary and secondary care. The relationships between CRP and lipids were determined using graphical techniques and empirical, non-parametric, best fit models.A total of 11 437 blood samples was included. We identified a significant (p0.001) biphasic relationship between TC and CRP: TC increased within the healthy CRP range of less than 5 mg/l, but decreased with CRP levels above 10 mg/l. The two effects approximately cancelled each other out in the intermediate CRP range of 5-10 mg/l. There was an inverse relationship between HDL-cholesterol and CRP.Lipid levels change significantly during inflammatory illness in a population with both acute and chronic conditions. These results provide a strong epidemiological basis for the better understanding of lipid changes in inflammatory conditions and with anti-inflammatory therapies. |
| Databáze: | OpenAIRE |
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