The Effect of Calcium Concentration on Calcium Uptake by Bone Cells Treated with Thyrocalcitonin (TCT) Hormone
| Autor: | Arieh Harell, Itzhak Binderman, Gideon A. Rodan |
|---|---|
| Rok vydání: | 1973 |
| Předmět: |
Calcitonin
Calcium Isotopes medicine.medical_specialty chemistry.chemical_element In Vitro Techniques Calcium Bone and Bones Endocrinology Internal medicine Calcium flux Bone cell medicine Animals Incubation Calcium metabolism Skull Drug Synergism Embryo Mammalian Culture Media Rats chemistry Calcium concentration Hormone |
| Zdroj: | Endocrinology. 92:550-555 |
| ISSN: | 1945-7170 0013-7227 |
| DOI: | 10.1210/endo-92-2-550 |
| Popis: | The effect of calcium concentration and thyrocalcitonin (TCT) on the uptake of calcium by bone cells in vitrowas studied. Both TCT and elevated calcium concentrations caused an accumulation of calcium in the cells. Given in conjunction, the effect of the two was larger than the separate effects added together. The amount of radiocalcium released by the cells during incubation was inversely related to the amount of calcium accumulated in the cells. The findings can be explained by assuming two types of calcium fluxes between medium and cells: a) a concentration dependent influx, and b) a constant rate calcium extrusion process subject to TCT inhibition. (Endocrinology92: 550O, 1973) |
| Databáze: | OpenAIRE |
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