The α3β4 nicotinic acetylcholine receptor antagonist 18-Methoxycoronaridine decreases binge-like ethanol consumption in adult C57BL/6J mice
| Autor: | Colton Ruggery, Helen M. Kamens, Carley N. Miller |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
Health (social science) Alcohol Drinking Alcohol abuse Alcohol Nicotinic Antagonists Receptors Nicotinic Pharmacology Toxicology Biochemistry Binge Drinking Mice 03 medical and health sciences Behavioral Neuroscience chemistry.chemical_compound Saccharin 0302 clinical medicine Animals Hypnotics and Sedatives 18-Methoxycoronaridine Medicine Ethanol metabolism Ethanol business.industry Antagonist General Medicine medicine.disease 030227 psychiatry Mice Inbred C57BL Nicotinic acetylcholine receptor Neurology chemistry Ibogaine Female business Locomotion 030217 neurology & neurosurgery |
| Zdroj: | Alcohol. 79:1-6 |
| ISSN: | 0741-8329 |
| Popis: | Binge alcohol drinking is a health burden in the United States, which has an alarming economic impact. Unfortunately, medications available for alcohol abuse have low efficacy or adverse side effects, creating a need to evaluate novel therapies. Growing research suggests that 18-Methoxycoronaridine (18-MC), an α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, may be effective at reducing ethanol consumption. However, its effects on binge-like ethanol consumption and other ethanol behaviors have not been examined. The present study examined the effect of α3β4 nAChRs antagonism on basal locomotor activity in male and female C57BL/6J mice. Next we tested the effect of 18-MC on binge-like ethanol consumption, ethanol-induced sedation, and ethanol metabolism. Finally, we tested the effect of α3β4 nAChRs on saccharin consumption to ensure effects were specific for ethanol. We observed that 18-MC decreased binge-like ethanol consumption without altering saccharin consumption, the sedative effects of ethanol, or ethanol metabolism. High doses of 18-MC caused locomotor sedation in C57BL/6J mice, but the effects were brief and likely did not contribute to differences in ethanol consumption. Our results support the involvement of the α3β4 nAChRs in binge-like ethanol intake, and further work should explore the use of 18-MC for treatment of alcohol use disorders. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect