A biomaterial with a channel-like pore architecture induces endochondral healing of bone defects
| Autor: | Petersen, A., Princ, A., Korus, G., Ellinghaus, A., Leemhuis, H., Herrera, A., Klaumünzer, A., Schreivogel, S., Woloszyk, A., Schmidt-Bleek, K., Geissler, S., Heschel, I., Duda, G. N. |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Fracture Healing
Tissue Scaffolds Science Stem Cells Biocompatible Materials Cell Count Cell Differentiation Article Bone and Bones Extracellular Matrix Rats Sprague-Dawley endochondral ossification Cell Movement Osteogenesis Animals Humans lcsh:Q Female Collagen lcsh:Science Porosity 600 Technik Medizin angewandte Wissenschaften::610 Medizin und Gesundheit::610 Medizin und Gesundheit |
| Zdroj: | Nature Communications Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018) |
| ISSN: | 2041-1723 |
| Popis: | Biomaterials developed to treat bone defects have classically focused on bone healing via direct, intramembranous ossification. In contrast, most bones in our body develop from a cartilage template via a second pathway called endochondral ossification. The unsolved clinical challenge to regenerate large bone defects has brought endochondral ossification into discussion as an alternative approach for bone healing. However, a biomaterial strategy for the regeneration of large bone defects via endochondral ossification is missing. Here we report on a biomaterial with a channel-like pore architecture to control cell recruitment and tissue patterning in the early phase of healing. In consequence of extracellular matrix alignment, CD146+ progenitor cell accumulation and restrained vascularization, a highly organized endochondral ossification process is induced in rats. Our findings demonstrate that a pure biomaterial approach has the potential to recapitulate a developmental bone growth process for bone healing. This might motivate future strategies for biomaterial-based tissue regeneration. A bioengineering approach to enhance the regeneration of large bone defects is lacking. Here, the authors show that a biomaterial scaffold with a channel-like pore architecture enables organized endochondral ossification through directional cell recruitment and extracellular matrix alignment. |
| Databáze: | OpenAIRE |
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