Brain imaging can predict neurodevelopmental outcome of Group B streptococcal meningitis in neonates

Autor: H.L.M. van Straaten, J.M.S. Martis, Levinus A. Bok, L S de Vries, Floris Groenendaal, F. J. J. Halbertsma
Rok vydání: 2018
Předmět:
Male
Pediatrics
medicine.medical_specialty
Group B streptococcus
Grey matter
Group B
Meningitis
Bacterial
Streptococcus agalactiae
03 medical and health sciences
Magnetic resonance imaging
Child Development
Cognition
0302 clinical medicine
Streptococcal Infections
030225 pediatrics
Intensive care
Journal Article
Humans
Medicine
Newborn infant
Pediatrics
Perinatology
and Child Health
030212 general & internal medicine
Retrospective Studies
Ultrasonography
Neurodevelopmental outcome
medicine.diagnostic_test
business.industry
Infant
Newborn
Brain
Infant
Retrospective cohort study
General Medicine
Odds ratio
medicine.disease
Perinatology
Magnetic Resonance Imaging
Hyperintensity
and Child Health
medicine.anatomical_structure
Motor Skills
Pediatrics
Perinatology and Child Health
Cranial ultrasound
Female
business
Meningitis
Zdroj: Acta Paediatrica, 108(5), 855. Wiley-Blackwell
ISSN: 1651-2227
0803-5253
DOI: 10.1111/apa.14593
Popis: Aim The association between cranial ultrasound (CUS) or magnetic resonance imaging (MRI) lesions and neonatal Group B streptococcal (GBS) meningitis outcome has not been studied in detail. Methods This retrospective study assessed CUS, cranial MRI and neurodevelopmental outcome in 50 neonates with GBS meningitis admitted to three neonatal intensive care units in the Netherlands between 1992 and 2014. Death, cognitive outcome and motor outcome below -1 SD were considered as adverse outcomes. Results CUS was available in all and MRIs in 31 infants (62%) with 28 CUS (56%) and 27 MRIs (87%) being abnormal. MRI lesions were multifocal (n = 10, 37%), bilateral (n = 22; 82%) and extensive (n = 11; 41%). A total of 10 died in the neonatal period. Median age at assessment was 24 months. Among survivors, abnormal cognitive outcome and motor outcome were seen in 23 and 20 patients, respectively. Abnormal CUS [odds ratio (OR) 5.3, p = 0.017], extensive bilateral deep grey lesions (OR 6.7, p = 0.035) and white matter lesions (OR 14.0, p = 0.039) correlated with abnormal motor outcome. Extensive bilateral deep grey matter lesions correlated with abnormal cognitive outcome (OR 8.1, p = 0.029). Conclusion Abnormal CUS and the most severely affected MRIs were associated with poor neurodevelopmental outcome in neonatal GBS meningitis.
Databáze: OpenAIRE
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