Controllable Soil Degradation Rate of 5-Substituted Sulfonylurea Herbicides as Novel AHAS Inhibitors
Autor: | Zheng-Ming Li, Yong-Hong Li, Bao-Lei Wang, An-Liang Chen, Shaa Zhou, Fan-Fei Meng, Bin Liu, Xuewen Hua, Jie Chen |
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Rok vydání: | 2020 |
Předmět: |
0106 biological sciences
Models Molecular medicine.drug_class Brassica 01 natural sciences Structure-Activity Relationship Soil retrogression and degradation medicine Organic chemistry Moiety Soil Pollutants Enzyme Inhibitors Plant Proteins Amaranthus Chemistry Herbicides 010401 analytical chemistry General Chemistry Crop rotation Sulfonylurea 0104 chemical sciences Acetolactate Synthase Kinetics Sulfonylurea Compounds Docking (molecular) Soil water General Agricultural and Biological Sciences 010606 plant biology & botany |
Zdroj: | Journal of agricultural and food chemistry. 68(10) |
ISSN: | 1520-5118 |
Popis: | Chlorsulfuron has been applied in wheat fields as a recognized herbicide worldwide, yet it was officially banned in China since 2014 for its soil persistence problem. On the basis of our previous research that 5-dimethylamino distinctively accelerated degradation rate in soils, a modified amino moiety (Ia-c) and monosubstituted amino group (Id-e) were introduced onto the fifth position of the benzene ring in sulfonylurea structures, as well as heterocyclic amino substituents (If-g) to seek a suitable soil degradation rate during such an in situ crop rotation system. Referring to the biological data and ScAHAS inhibition and ScAHAS docking results, they turned out to be AHAS inhibitors with high potent herbicidal activities. The various influence on soil degradation rate along with crop safety indicated that different substituents on the fifth position have exerted an apparent impact. Their united study of structure-activity-safety-degradation relationship has great potential to provide valuable information for further development of eco-friendly agrochemicals. |
Databáze: | OpenAIRE |
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