Postoperative venous thromboembolism and brain tumors: Part II. Hemostatic profile
| Autor: | Pia Glas-Greenwalt, Raymond Sawaya |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment Brain tumor Fibrinogen Gastroenterology Plasminogen Activators Postoperative Complications Internal medicine Fibrinolysis Plasminogen Activator Inhibitor 1 medicine Meningeal Neoplasms Humans Prospective Studies Disseminated intravascular coagulation Hemostasis business.industry Brain Neoplasms Plasminogen Disseminated Intravascular Coagulation Middle Aged medicine.disease Thrombosis Neoplasm Proteins Venous thrombosis Neurology Oncology Coagulation Anesthesia Neurology (clinical) Chronic disseminated intravascular coagulation Blood Coagulation Tests Disease Susceptibility business Glioblastoma Meningioma medicine.drug |
| Zdroj: | Journal of neuro-oncology. 14(2) |
| ISSN: | 0167-594X |
| Popis: | Preoperative hemostatic data were obtained on 42 brain tumor patients and correlated with the subsequent occurrence of venous thrombosis detected with 1211-labeled fibrinogen leg scans. The occurrence of thrombosis correlated significantly with an increased prothrombin time, plasminogen, and total fibrinolytic activity and a decreased fibrinogen level. This overall trend in the group of patients with postoperative thrombosis indicates that the hemostatic disorder noted in brain tumor patients is most closely related to a subclinical form of chronic disseminated intravascular coagulation syndrome. Differences in hemostatic parameters seen with the various types of brain tumors suggest that biological factors specific to each tumor are likely responsible for the described hemostatic disorder and support the need for further research directed at the tumor tissue level. |
| Databáze: | OpenAIRE |
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