Effects of maropitant in cats receiving dexmedetomidine and morphine
| Autor: | Daniel M. Sakai, Manuel Martin-Flores, McKenzie M Learn, Jordyn M. Boesch, Luis Campoy, Robin D. Gleed, Alicia Mastrocco |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Quinuclidines
Visual Analog Scale Vomiting 040301 veterinary sciences Nausea Visual analogue scale Injections Subcutaneous medicine.medical_treatment Cat Diseases Injections Intramuscular 0403 veterinary science chemistry.chemical_compound medicine Animals Drug Interactions Single-Blind Method Retching Dexmedetomidine Saline CATS Morphine General Veterinary business.industry 0402 animal and dairy science 04 agricultural and veterinary sciences Analgesics Non-Narcotic 040201 dairy & animal science Analgesics Opioid chemistry Anesthesia Cats Antiemetics Female medicine.symptom Maropitant business medicine.drug |
| Zdroj: | Journal of the American Veterinary Medical Association. 248:1257-1261 |
| ISSN: | 0003-1488 |
| Popis: | OBJECTIVE To evaluate the effects of maropitant in cats receiving dexmedetomidine and morphine. DESIGN Randomized controlled trial. ANIMALS 66 healthy female domestic shorthair cats. PROCEDURES Cats were randomly assigned to receive maropitant (1 mg/kg [0.45 mg/lb], SC; maropitant group; n = 32) or saline (0.9% NaCl) solution (0.1 mL/kg [0.045 mL/lb], SC; control group; 34) 20 hours before IM administration of dexmedetomidine (20 μg/kg [9.1 μg/lb]) and morphine (0.1 mg/kg). Following administration of dexmedetomidine and morphine, the incidences of emesis, retching, and signs of nausea (sialorrhea and lip licking) were compared between the 2 groups. The aversive behavioral response of each cat to injection of maropitant or saline solution was scored on a visual analogue scale by each of 4 observers who were unaware of the treatment administered. RESULTS Only 1 of 32 cats in the maropitant group vomited, whereas 20 of 34 control cats vomited. The incidences of emesis and retching for the maropitant group were significantly lower than those for the control group. The incidence of signs of nausea did not differ between the 2 groups. Visual analogue scale scores for the maropitant group were significantly higher than those for the control group. CONCLUSIONS AND CLINICAL RELEVANCE Results of the present study indicated that administration of maropitant to healthy cats approximately 20 hours prior to administration of dexmedetomidine and morphine significantly decreased the incidence of emesis but did not decrease the incidence of signs of nausea. However, maropitant appeared to cause substantial discomfort when injected SC. |
| Databáze: | OpenAIRE |
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