Intranasal dexmedetomidine in pediatrics: update of current knowledge
| Autor: | Angela Amigoni, Geremia Zito Marinosci, Rosa Puzzutiello, Sergio Picardo, Maria Cristina Mondardini, Francesca Vitale, Paolo Cortellazzi, Alessandra Di Palma, Cristina Navarra, Giorgio Conti, Laura Rinaldi |
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| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
business.industry Premedication Treatment outcome MEDLINE Analgesics Non-Narcotic Pediatrics Treatment Outcome Anesthesiology and Pain Medicine Deep sedation Intranasal administration Settore MED/41 - ANESTESIOLOGIA Humans Medicine Nasal administration Dexmedetomidine Child business Intensive care medicine Administration Intranasal medicine.drug |
| Zdroj: | Minerva Anestesiologica. 85 |
| ISSN: | 1827-1596 0375-9393 |
| DOI: | 10.23736/s0375-9393.19.13820-5 |
| Popis: | Intranasal dexmedetomidine, although still off-label, recently boasted an increasing consensus for different uses, namely, in diagnostic non-painful procedures, in painful procedures and in surgical premedication. However, at present, there is no consensus regarding indications, dosage and timing for administration. This article aims to provide a comprehensive literature analysis and summarize the more recent evidence of research on pediatric intranasal dexmedetomidine, in the effort to better delineate usefulness and limits for each specific indication. In summary, available pediatric evidence confirms efficacy and safety of dexmedetomidine for intranasal administration. Pharmacological profile for the various pediatric ages and procedures still needs quality studies and pharmacokinetic in-depth analysis. |
| Databáze: | OpenAIRE |
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