Comparison of Cancer Cell Elasticity by Cell Type
| Autor: | Woochul Yang, Donggerami Moon, Sangwoo Kwon, Kyung Sook Kim |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Cell type
02 engineering and technology 010402 general chemistry 01 natural sciences Cellular elasticity cervix cancer F-actin breast cancer Breast cancer medicine Elasticity (economics) Lung cancer Cervix Actin atomic force microscopy Lung Chemistry 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences lung cancer medicine.anatomical_structure Oncology Cancer cell Cancer research 0210 nano-technology Research Paper |
| Zdroj: | Journal of Cancer |
| ISSN: | 1837-9664 |
| DOI: | 10.7150/jca.45897 |
| Popis: | Lower cellular elasticity is a distinguishing feature of cancer cells compared with normal cells. To determine whether cellular elasticity differs based on cancer cell type, cells were selected from three different cancer types including breast, cervix, and lung. For each cancer type, one counterpart normal cell and three types of cancer cells were selected, and their elasticity was measured using atomic force microscopy (AFM). The elasticity of normal cells was in the order of MCF10A > WI-38 ≥ Ect1/E6E7 which corresponds to the counterpart normal breast, lung, and cervical cancer cells, respectively. All cancer cells exhibited lower elasticity than their counterpart normal cells. Compared with the counterpart normal cells, the difference in cellular elasticity was the greatest in cervical cancer cells, followed by lung and breast cancer cells. This result indicates lower elasticity is a unique property of cancer cells; however, the reduction in elasticity may depend on the histological origin of the cells. The F-actin cytoskeleton of cancer cells was different in structure and content from normal cells. The F-actin is mainly distributed at the periphery of cancer cells and its content was mostly lower than that seen in normal cells. |
| Databáze: | OpenAIRE |
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