Microsampling: considerations for its use in pharmaceutical drug discovery and development
Autor: | Yang Xu, Neil Spooner, Kenneth D. Anderson, Mike Lee, Joe Siple, Enaksha R Wickremsinhe |
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Rok vydání: | 2019 |
Předmět: |
Pharmaceutical drug
medicine.medical_specialty Bioanalysis Drug discovery business.industry Clinical events medicine.medical_treatment Clinical Biochemistry Analytic Sample Preparation Methods Sampling (statistics) General Medicine Specimen Handling Analytical Chemistry Medical Laboratory Technology Drug development Drug Discovery medicine Humans Medical physics General Pharmacology Toxicology and Pharmaceutics business |
Zdroj: | Bioanalysis. 11:1015-1038 |
ISSN: | 1757-6199 1757-6180 |
Popis: | There is growing interest in the implementation of microsampling approaches for the quantitation of circulating concentrations of analytes in biological samples derived from nonclinical and clinical studies involved in drug development. This interest is partly due to the ethical advantages of taking smaller blood volumes, particularly for studies in rodents, children and the critically ill. In addition, these technologies facilitate sampling to be performed in previously intractable locations and occasions. Further, they enable the collection of samples for additional purposes (extra time points, biomarkers, sampling during a clinical event, etc). This article gives a comprehensive insight to the utilization of these approaches in drug discovery and development, and provides recommendations for best practice for nonclinical, clinical and bioanalytical aspects. |
Databáze: | OpenAIRE |
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