Intraoperative Portal Flow of Less Than 1 Liter per Minute After Orthotopic Liver Transplantation Is Not Associated Per Se With an Increased Rate of Early Graft Dysfunction
| Autor: | L. Martinez-Indart, Mikel Prieto, A. Matarranz, Patricia Ruiz, Andrés Valdivieso, A. Ventoso, Mikel Gastaca, J. Ortiz de Urbina, I. Palomares |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Graft dysfunction medicine.medical_specialty Orthotopic liver transplantation 030230 surgery Group A Group B 03 medical and health sciences 0302 clinical medicine Odds Ratio Medicine Humans Retrospective Studies Transplantation business.industry Incidence (epidemiology) Incidence Graft Survival Liter Retrospective cohort study Middle Aged Surgery Liver Transplantation medicine.anatomical_structure Liver 030211 gastroenterology & hepatology Female Primary Graft Dysfunction business Artery Liver Circulation |
| Zdroj: | Transplantation proceedings. 48(7) |
| ISSN: | 1873-2623 |
| Popis: | The aim of this study was to determine whether a portal flow of 1,000 mL/min in orthotopic liver transplantation (OLT) is associated with a higher incidence of early graft dysfunction (EGD) and graft loss.A retrospective study was performed of 540 OLTs carried out consecutively from December 2004 to December 2013. Patients were divided into 2 groups: group A, portal flow 1,000 mL/min; and group B, portal flow1,000 mL/min. We studied the incidence of EGD and graft survival. A subanalysis was performed to define the minimum acceptable portal flow/100 g of liver weight to reduce the development EGD and graft loss.Group A included 29 patients and group B, 511 patients. Group A had significantly lower-weight donors and recipients, female recipients with cholestatic disease, lower MELD scores, and lower hepatic artery flow. EGD occurred in 7 patients in group A (24.1%) versus 101 patients in group B (19.8%; P = .43). No significant differences were found in 1- and 5-year graft survival. A portal flow of 80 mL/min/100 g of liver weight was related to a significantly higher risk of developing EGD (odds ratio, 4.35; 95% confidence interval [CI], 1.46-12.91; P = .008) and graft loss (hazard ratio, 4.05; 95% CI, 1.32-12.42; P = .014).Intraoperative portal flow of 1,000 mL/min in OLT was not related per se with a higher incidence of EGD or graft loss. Significantly higher risk of developing EGD and graft loss was associated with a portal flow of 80 mL/min/100 g of liver weight. |
| Databáze: | OpenAIRE |
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