Characterization of hydrodynamics in membrane chromatography devices using magnetic resonance imaging and computational fluid dynamics
| Autor: | Chalore Teepakorn, Denis Grenier, Catherine Charcosset, Koffi Fiaty |
|---|---|
| Přispěvatelé: | Laboratoire d'automatique et de génie des procédés (LAGEP), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-École Supérieure Chimie Physique Électronique de Lyon-Centre National de la Recherche Scientifique (CNRS), Plateforme d'Imagerie Multimodale LyonTech (PILoT), Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Rok vydání: | 2016 |
| Předmět: |
Whole membrane
General Chemical Engineering 02 engineering and technology Computational fluid dynamics 01 natural sciences [CHIM.GENI]Chemical Sciences/Chemical engineering [SPI.GPROC]Engineering Sciences [physics]/Chemical and Process Engineering ComputingMilieux_MISCELLANEOUS chemistry.chemical_classification geography Chromatography geography.geographical_feature_category business.industry Biomolecule 010401 analytical chemistry General Chemistry Velocimetry 021001 nanoscience & nanotechnology Inlet 0104 chemical sciences Membrane Axial compressor chemistry Vector field 0210 nano-technology business |
| Zdroj: | Chemical Engineering Research and Design Chemical Engineering Research and Design, Elsevier, 2016, 113, pp.61-73. ⟨10.1016/j.cherd.2016.06.027⟩ |
| ISSN: | 0263-8762 |
| Popis: | Membrane chromatography (MC) is increasingly used in downstream processes for biomolecule purification as a large range of axial or radial flow commercial membranes is available. The design of these devices plays a major role on flow distribution and biomolecule binding. To better understand the hydrodynamic in MC devices, the velocity field was measured for the first time using magnetic resonance imaging (MRI) and calculated by computational fluid dynamics (CFD) on reconstructed geometries obtained by MRI. The CFD model solved Navier⿿Stokes and Brinkman equations in the free and membrane regions, respectively. Both axial flow and radial flow devices were investigated. For the axial flow device, the velocities were found higher at the periphery for all membrane bed heights. This result suggests that the whole membrane housing has an effect on flow distribution, the inlet and outlet distributors as well as the peripheral walls of the module. In the radial flow device, a high decrease in velocity was observed along the membrane bed height, which could be due to the reduction of the diameter section at the module outlet. Overall, it was concluded that MRI and CFD are powerful methods to better understand the hydrodynamics within MC devices. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |
Full Text from ScienceDirect