Continuous Glucose Monitoring Reveals Delayed Nocturnal Hypoglycemia After Intermittent High-Intensity Exercise in Nontrained Patients with Type 1 Diabetes
| Autor: | Paola Pavan, Marco Zaccaria, Erica Brugin, Angelo Avogaro, Alberto Maran, Barbara Bonsembiante, Andrea Ermolao |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Monitoring Ambulatory Hypoglycemia Diabetes Therapy Norepinephrine Oxygen Consumption Endocrinology Heart Rate Internal medicine Diabetes mellitus Heart rate medicine Humans Hypoglycemic Agents Insulin FAILURE Lactic Acid Exercise EUGLYCEMIC EXERCISE RISK Type 1 diabetes Cross-Over Studies ANTECEDENT HYPOGLYCEMIA COUNTERREGULATORY RESPONSES MODERATE EXERCISE INDIVIDUALS business.industry medicine.disease Crossover study Medical Laboratory Technology Diabetes Mellitus Type 1 Ambulatory Cardiology Energy Metabolism business |
| Zdroj: | Diabetes Technology & Therapeutics. 12:763-768 |
| ISSN: | 1557-8593 1520-9156 |
| Popis: | Exercise is a cornerstone of diabetes therapy in type 1 diabetes mellitus (DMT1) patients. The type of exercise is important in determining the propensity to hypoglycemia. We assessed, by continuous glucose monitoring (CGM), the glucose profiles during and in the following 20h after a session of two different types of exercise.Eight male volunteers with well-controlled DMT1 were studied. They underwent 30min of both intermittent high-intensity exercise (IHE) and moderate-intensity exercise (MOD) in random order. Expired air was recorded during exercise, while metabolic and hormonal determinations were performed before and for 120 min after exercises. The CGM system and activity monitor were applied for the subsequent 20h.Blood glucose level declined during both type of exercise. At 150 min following the start of exercise, plasma glucose content was slightly higher after IHE. No changes were observed in plasma insulin concentration. A significant increase of norepinephrine concentration was noticed during IHE. Between midnight and 6:00 a.m. the glucose levels were significantly lower after IHE than those observed after MOD (area under the curve, 23.3 ± 3 vs. 16 ± 3 mg/dL/420 min [P = 0.04]; mean glycemia at 3 a.m., 225 ± 31 vs. 147 ± 17 mg/dL [P0.05]). The number of hypoglycemic episodes after IHE was higher than that observed after MOD (seven vs. two [P0.05]).We demonstrate that (1) CGM is a useful approach in DMT1 patients who undergo an exercise program and (2) IHE is associated with delayed nocturnal hypoglycemia. |
| Databáze: | OpenAIRE |
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