Single-Nucleotide Polymorphism in WT1 Gene in a Hyperplastic Intralobar Nephrogenic Rest With Botryoid Protrusion
| Autor: | Kentaro Mizuno, Shoichiro Iwatsuki, Yutaro Hayashi, Yoshiyuki Kojima, Kenjiro Kohri, Keiichi Tozawa |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Male
Nephrology medicine.medical_specialty Genes Wilms Tumor Urology medicine.medical_treatment Polymorphism Single Nucleotide Wilms Tumor Internal medicine medicine Humans Kidney Pelvis Nephrogenic rest Kidney Hyperplasia business.industry Wilms' tumor medicine.disease Kidney Neoplasms Nephrectomy medicine.anatomical_structure Intralobar Nephrogenic Rest Child Preschool Cancer research Ureter business Renal pelvis |
| Zdroj: | Urology. 76:149-152 |
| ISSN: | 0090-4295 |
| DOI: | 10.1016/j.urology.2009.09.012 |
| Popis: | Nephrogenic rests are nodular collections of undifferentiated renal blastema cells in the postnatal kidney that are recognized as putative precursor lesions of Wilms tumor. In this study, we report the case of a 3-year-old boy who was diagnosed with a hyperplastic intralobar nephrogenic rest extending through the renal pelvis and ureter. After radical nephrectomy, adjuvant chemotherapy was performed as done in stage II Wilms tumor. We also investigated the mutation of the WT1 gene and identified a related single-nucleotide polymorphism (rs16754). We consider that not only various genetic mutations but also single-nucleotide polymorphisms or other epigenetic factors might be involved in the development of Wilms tumor. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect