Changes in erythrocyte membrane fatty acids during a clinical trial of eicosapentaenoic acid (EPA) supplementation in schizophrenia
| Autor: | Dinie Hon, Martin Kidd, Sulene van der Merwe, Christo Myburgh, Piet Oosthuizen, Robin Emsley, Cornelius M. Smuts, Susan J. van Rensburg |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Erythrocytes Adolescent Docosahexaenoic Acids Linoleic acid Biology Neuropsychological Tests Biochemistry Fatty Acids Monounsaturated Cellular and Molecular Neuroscience chemistry.chemical_compound Disability Evaluation Membrane Lipids Young Adult Internal medicine medicine Humans Omega 3 fatty acid Aged chemistry.chemical_classification Dyskinesias alpha-Linolenic acid Fatty Acids Fatty acid alpha-Linolenic Acid Middle Aged Eicosapentaenoic acid Up-Regulation Endocrinology Treatment Outcome chemistry Eicosapentaenoic Acid Docosahexaenoic acid Omega-6 fatty acid Saturated fatty acid Dietary Supplements Schizophrenia Female Neurology (clinical) |
| Zdroj: | Metabolic brain disease. 24(4) |
| ISSN: | 1573-7365 |
| Popis: | In a previously reported double-blind, placebo-controlled trial of eicosapentaenoic acid (EPA) as supplemental treatment in 40 patients with schizophrenia, we found significant improvement in symptoms as measured by the Positive and Negative Syndrome Scale (PANSS) compared to placebo (Emsley et al. 2002). Here we report changes in fatty acid composition of erythrocyte membranes in the same sample (n = 16 in each group). After 12 weeks of receiving EPA, levels of several saturated and mono-unsaturated fatty acids decreased significantly while levels of n-3 fatty acids increased significantly compared to the placebo group. Increases of n-3 and n-6 fatty acids in the erythrocyte membranes were greater in subjects who improved more than 20% on overall symptoms. Changes in fatty acids correlated significantly with improvement in PANSS sub-scale scores, more so in females than in males. Docosahexaenoic acid (DHA) (22:6n-3) levels increased less than expected, suggesting a possible defect in synthesis or incorporation of DHA into membranes in schizophrenia. Improvement in dyskinesia correlated significantly with an increase in alpha-linolenic acid (18:3n-3; p = 0.03), and a decrease in 20:1n-9 (p = 0.005). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink