Assessment of Pretreatment Neutrophil/Lymphocyte Ratio and Platelet/Lymphocyte Ratio in Prognosis of Oral Squamous Cell Carcinoma
| Autor: | Krishnamachar Harish, Kavitha Prasad, Aravind S. Kapali, Sanah Tazeen, Satish Chandramouli, Parimala Sagar |
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| Rok vydání: | 2019 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Neutrophils Gastroenterology 03 medical and health sciences 0302 clinical medicine Internal medicine Carcinoma Medicine Humans Lymphocytes Stage (cooking) Lymph node Survival analysis Retrospective Studies Mouth neoplasm Univariate analysis business.industry Hazard ratio 030206 dentistry medicine.disease Prognosis Confidence interval medicine.anatomical_structure Otorhinolaryngology 030220 oncology & carcinogenesis Carcinoma Squamous Cell Surgery Mouth Neoplasms Oral Surgery business |
| Zdroj: | Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons. 78(6) |
| ISSN: | 1531-5053 |
| Popis: | Purpose Recent data have provided evidence of systemic inflammatory markers playing an important role in determining the disease-free survival (DFS) and overall survival (OS) of patients with oral squamous cell carcinoma (OSCC). The aim of the present study was to determine the prognosis of OSCC using the preoperative neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR). Patients and Methods We enrolled 130 patients with OSCC who received treatment in the present retrospective study. Both PLR and NLR correlated with the demographic data, tumor characteristics, and prognosis. The optimal cutoff for PLR and NLR was determined by receiver operating characteristic curve analysis and was 142 and 3.1 for PLR and NLR, respectively. The prognostic significance of both markers was determined by univariate and multivariate analysis. Survival curves were plotted using the Kaplan-Meier method. Results The clinicopathologic variables correlated with cumulative survival on univariate analysis. Advanced clinical lymph node stage (P = .001), pathologic lymph node stage (P = .001), pathologic tumor stage (P = .049), pathologic TNM stage (P = .006), receipt of multimodality treatment (P = .013), and high PLRs (P = .001) and NLRs (P = .002) showed a statistically significant association with shorter DFS. A multivariate Cox proportional hazard regression model demonstrated that a high PLR (hazard ratio [HR], 2.998; 95% confidence interval [CI], 1.128 to 7.968; P = .028) and patient age (HR, 1.100; 95% CI, 0.750 to 1.613; P = .025) were independent factors for determining DFS and OS. Conclusions We observed that high PLRs and NLRs were significant in determining the prognosis. The PLR was superior to the NLR in determining DFS and OS and can be used as an independent prognostic indicator in patients with OSCC. |
| Databáze: | OpenAIRE |
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