Malignant Melanoma of the Nasal Septum
| Autor: | Davide Lazzeri, Maurizio De Rosa, Pietro Massei, Alessandro Giacomina, Giordano Giannotti, Livio Colizzi, Marcello Pantaloni, Tommaso Agostini |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Nose Neoplasms Fatal Outcome medicine Nasal septum Humans Neoplasm Invasiveness Melanoma Neoadjuvant therapy Aged Nasal Septum Frontal sinus medicine.diagnostic_test business.industry Mucosal melanoma Endoscopy General Medicine medicine.disease Neoadjuvant Therapy Radiation therapy Nasal Mucosa medicine.anatomical_structure Otorhinolaryngology Frontal Sinus Radiotherapy Adjuvant Surgery Radiology business Paranasal Sinus Neoplasms Rare disease |
| Zdroj: | Journal of Craniofacial Surgery. 21:1957-1960 |
| ISSN: | 1049-2275 |
| DOI: | 10.1097/scs.0b013e3181f4eee6 |
| Popis: | Primary malignant melanoma involving the nasal and paranasal sinus mucosa is a rare neoplasm, accounting for less than 1% of all melanomas. Being more aggressive than its cutaneous counterpart, it carries a poor prognosis. We report a case arising from the nasal septum mucosae in a 78-year-old man. We describe clinical features, diagnosis, and treatment of this rare disease along with a review of the pertinent literature. Endoscopic resection of the neoplasm was performed, enabling diagnosis of sinonasal mucosal melanoma involving the frontal sinus floor. Because the patient was too compromised to achieve radical surgical approach (craniofacial resection), he underwent radiation therapy. Through this article, we wish to emphasize that early diagnosis with a high index of suspicion is critical because this type of tumor is extremely aggressive. Its location and relatively nonspecific features frequently delay diagnosis, and its rarity avoids an optimal treatment guideline setting. |
| Databáze: | OpenAIRE |
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