A 25-year-old woman with a gastric GIST and a PET-positive epicardial tumor
| Autor: | Felix M. Mottaghy, Hans J. Brambs, Guido Adler, N. M. Blumstein, Thomas F. E. Barth, Martin Höher, Andreas Hannekum, Sven N. Reske, Volker Kächele, Sandra Pauls, Peter Möller, Thomas Seufferlein, Martin Jeltsch |
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| Rok vydání: | 2006 |
| Předmět: |
Endoscopic ultrasound
Adult Abdominal pain medicine.medical_specialty Pathology Gastrointestinal Stromal Tumors Coronary Angiography Diagnosis Differential Heart Neoplasms Neoplasms Multiple Primary Paraganglioma Gastrectomy Stomach Neoplasms medicine Biomarkers Tumor Pyloric Antrum Humans Stromal tumor Ultrasonography Paraganglioma Extra-Adrenal medicine.diagnostic_test business.industry Remission Induction General Medicine Syndrome medicine.disease Magnetic Resonance Imaging Endoscopy Oncology Gastric Leiomyosarcoma Positron-Emission Tomography Angiography Female Radiology medicine.symptom business Tomography X-Ray Computed Case Management Pericardium Chondroma |
| Zdroj: | Nature clinical practice. Oncology. 4(3) |
| ISSN: | 1743-4262 |
| Popis: | Carney's triad is a syndrome consisting of three rare neoplasms: gastric leiomyosarcoma, extra-adrenal paraganglioma and pulmonary chondroma. The article by Kachele et al. describes the case of a young woman who presented with a gastrointestinal stromal tumor and metastatic epicardial paraganglioma. The patient underwent an extended hemigastrectomy and cardiac surgery and remained free of recurrent disease during the follow-up period. This is the first report of an epicardial paraganglioma within a Carney's triad and the authors discuss the diagnostic workup and management of patients with Carney's syndrome. Background A 25-year-old woman presented with a history of abdominal pain. Endoscopy of the upper gastrointestinal tract revealed a tumor that protruded into the prepyloric antrum. After resection, a 'high-risk' gastrointestinal stromal tumor was histologically confirmed. Investigations Endoscopy, endoscopic ultrasound, hemigastrectomy, [18F]-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT scan, histological examination, immunohistochemistry, cardiac MRI, high-resolution CT with electrocardiogram gating, CT angiography, and cardiac surgery. Diagnosis Gastrointestinal stromal tumor, epicardial paraganglioma, and Carney's syndrome. Management Abdominal ultrasound and endoscopy combined with endoscopic ultrasound, annual FDG-PET/CT scan. |
| Databáze: | OpenAIRE |
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