Corticosterone enhances CSD susceptibility via glucocorticoid receptor activation in familial hemiplegic migraine 1 Cacna1a knock-in mice
| Autor: | Amj van den Maagdenberg, Katharina Eikermann-Haerter, Cenk Ayata, Onno C. Meijer, M L de Groote, Reinald Shyti, S.H. van Heiningen, Ferrari, Else A. Tolner |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Voltage-dependent calcium channel business.industry Clinical Neurology General Medicine medicine.disease chemistry.chemical_compound Glutamatergic Anesthesiology and Pain Medicine Glucocorticoid receptor Endocrinology chemistry Migraine Corticosterone Gene knockin Internal medicine Cortical spreading depression Poster Presentation Medicine Neurology (clinical) business Neuroscience Familial hemiplegic migraine |
| Zdroj: | Journal of Headache and Pain, 14 The Journal of Headache and Pain |
| Popis: | FHM1 mutant mice carrying the R192Q gain-of-function mutation in CaV2.1 (P/Q-type) calcium channels display enhanced glutamatergic transmission and increased propensity for cortical spreading depression (CSD;1,2). Corticosteroids released after stress also enhance glutamatergic transmission but the relationship between stress and migraine is not well understood. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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