Nef and LTR Sequence Variation from Sequentially Derived Human Immunodeficiency Virus Type 1 Isolates
| Autor: | Alfred Saah, Anahid Birdwell, Max Q. Arens, Lee Ratner, Alan R. Templeton, Richard Markham, Terry McNearney, Zuzana Hornickova |
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| Rok vydání: | 1995 |
| Předmět: |
viruses
Molecular Sequence Data Human immunodeficiency virus (HIV) HIV Infections Viral quasispecies Disease Biology medicine.disease_cause Gene Products nef DNA sequencing Virology medicine Humans Point Mutation Amino Acid Sequence nef Gene Products Human Immunodeficiency Virus Sequence variation HIV Long Terminal Repeat Sequence (medicine) Genetics Point mutation Genetic Variation virus diseases HIV-1 Adaptation |
| Zdroj: | Virology. 208:388-398 |
| ISSN: | 0042-6822 |
| DOI: | 10.1006/viro.1995.1166 |
| Popis: | Variation in HIV-1 nef and LTR DNA sequences was assessed longitudinally during disease progression in four HIV-1infected subjects. Point mutations were found among quasispecies obtained at a single time point in each individual, with increasing diversity with disease progression in two of three patients for whom sufficient data were available for analysis. Deletions and rearrangements were more common in late than early stages of disease. Continued sequence evolution in HIV-1 quasispecies with nef deletions along with coexistence of nef-bearing quasispecies suggest that nef-deleted quasispecies are capable of replication in vivo, possibly complemented by quasispecies lacking such deletions and/or by adaptation to a specialized niche within the patients. |
| Databáze: | OpenAIRE |
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