Asymmetric Synthesis of Indolines Bearing a Benzylic Quaternary Stereocenter through Intramolecular Arylcyanation of Alkenes
| Autor: | Yoshiaki Nakao, Shiro Ebata, Tamejiro Hiyama, Jen-Chieh Hsieh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
indoline
Bearing (mechanical) Stereochemistry Organic Chemistry asymmetric synthesis Enantioselective synthesis chemistry.chemical_element C-C bond activation Medicinal chemistry Catalysis law.invention Stereocenter chemistry.chemical_compound Nickel nickel chemistry law Intramolecular force Indoline carbocyanation |
| Zdroj: | SYNLETT. (11):1709-1711 |
| ISSN: | 0936-5214 |
| Popis: | Enantioselective intramolecular arylcyanation of olefins is achieved by a Ni(cod) 2 /chiral phosphinoxazoline/AlMe 2 Cl catalyst to give chiral, substituted indoline derivatives bearing a benzylic quaternary stereocenter in high yields with good to excellent enantioselectivities. |
| Databáze: | OpenAIRE |
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