STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)–STAT3 pathway

Autor:	Michael Koo, James Turkson, David L. Huso, Tait Huso, Patrick T. Gunning, Lingling Xian, Guosheng Liu, Brent D. G. Page, Amy Belton, Li Z. Luo, Linda M.S. Resar
Rok vydání:	2016
Předmět:	STAT3 Transcription Factor 0301 basic medicine Cancer Research Mice Nude Antineoplastic Agents Malignancy Jurkat cells Article Jurkat Cells Mice 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation Precursor cell Tumor Cells Cultured medicine Animals Humans Cell Lineage HMGA1a Protein STAT3 Cause of death Sulfonamides biology Gene Expression Regulation Leukemic business.industry Precursor Cells B-Lymphoid Cancer Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Xenograft Model Antitumor Assays HMGA1 Up-Regulation Aminosalicylic Acids 030104 developmental biology Oncology 030220 oncology & carcinogenesis Immunology biology.protein Cancer research business Signal Transduction
Zdroj:	Leukemia & Lymphoma. 57:2681-2684
ISSN:	1029-2403 1042-8194
Popis:	Despite dramatic improvements in treatment and survival, acute lymphoid malignancies remain the leading cause of death in children with cancer and a highly lethal malignancy in adults.[1] Acute lym...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce6544fa822f58857d3b76915d38b15e https://doi.org/10.3109/10428194.2016.1153089 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.