AGO unchained: Canonical and non-canonical roles of Argonaute proteins in mammals
| Autor: | Laura Sala, Srividya Chandrasekhar, Joana A. Vidigal |
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| Rok vydání: | 2019 |
| Předmět: |
Models
Molecular 0303 health sciences Multiprotein complex Protein Conformation Argonaute Biology Article Cell biology 03 medical and health sciences MicroRNAs 0302 clinical medicine Human disease Non canonical Gene Expression Regulation Translational repression 030220 oncology & carcinogenesis Multigene Family microRNA Argonaute Proteins Animals Humans Amino Acid Sequence RNA Small Interfering Gene 030304 developmental biology |
| Zdroj: | Front Biosci (Landmark Ed) |
| ISSN: | 2768-6698 |
| Popis: | Argonaute (AGO) proteins play key roles in animal physiology by binding to small RNAs and regulating the expression of their targets. In mammals, they do so through two distinct pathways: the miRNA pathway represses genes through a multiprotein complex that promotes both decay and translational repression; the siRNA pathway represses transcripts through direct Ago2-mediated cleavage. Here, we review our current knowledge of mechanistic details and physiological requirements of both these pathways and briefly discuss their implications to human disease. |
| Databáze: | OpenAIRE |
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