Can gut microbes predict efficacy and toxicity of combined immune checkpoint blockade?

Autor:	Khiem C. Lam, Romina S. Goldszmid
Rok vydání:	2021
Předmět:	Cancer Research biology business.industry Gut flora biology.organism_classification Bioinformatics digestive system Immune checkpoint Gastrointestinal Microbiome Blockade Oncology Leverage (negotiation) Toxicity Humans Medicine CTLA-4 Antigen business Immune Checkpoint Inhibitors
Zdroj:	Cancer Cell. 39:1314-1316
ISSN:	1535-6108
DOI:	10.1016/j.ccell.2021.09.013
Popis:	A recent report in Nature Medicine pinpoints a role for gut microbiota in response and toxicity to combined immune checkpoint blockade targeting CTLA-4 and PD-1. This emergent study provides insights that can be used to leverage microbiota in the design of anticancer therapies to mitigate toxicity while enhancing efficacy.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce638515607d9c283324b1b06baca4e3 https://doi.org/10.1016/j.ccell.2021.09.013 Zobrazit plný text záznamu