Age-Dependent Control of Energy Homeostasis by Brown Adipose Tissue in Progeny Subjected to Maternal Diet-Induced Fetal Programming

Autor: Virginie Casamento, Estelle Roger, Charlotte Hinault, Pascal Lopez, Patricia Lebrun, Olivier Dumortier, Céline Jousse, Hereroa Johnston, Didier F. Pisani, Pierre Fafournoux, N Gautier, Ez-Zoubir Amri, Marc Prentki, Emmanuel Van Obberghen
Přispěvatelé: Institute of research on Cancer and Aging (IRCAN), Université de Nice Sophia-Antipolis (UNSA), Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de la Recherche Scientifique (CNRS), Institut de Biologie Valrose (IBV), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CRCHUM, Université de Montréal (UdeM), Centre Hospitalier Universitaire de Nice (CHU de Nice), EU FP7 project DIABAT (HEALTH-F2-2011-278373), Agence Nationale de la Recherche (ANR) (ANR-RPV12004AAA ANR-11-LABX-0028-01), European Foundation for the Study of Diabetes (EFSD/Lilly, European Diabetes Research Program), Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), Université de Montréal, Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre Hospitalier Universitaire de Nice (CHU Nice)
Rok vydání: 2016
Předmět:
0301 basic medicine
Blood Glucose
Male
Endocrinology
Diabetes and Metabolism
Adipose tissue
Type 2 diabetes
Energy homeostasis
Fetal Development
Adipose Tissue
Brown
Pregnancy
Brown adipose tissue
Glucose homeostasis
Homeostasis
Insulin
rat
désordre métabolique
2. Zero hunger
Glucose tolerance test
medicine.diagnostic_test
Age Factors
Postprandial Period
Immunohistochemistry
3. Good health
medicine.anatomical_structure
Prenatal Exposure Delayed Effects
Female
Body Temperature Regulation
medicine.medical_specialty
diabète de type 2
Offspring
Lipolysis
Blotting
Western
Biology
Diet
High-Fat
Real-Time Polymerase Chain Reaction
03 medical and health sciences
Insulin resistance
Internal medicine
Internal Medicine
medicine
hibernating gland
Diet
Protein-Restricted
Animals
Obesity
Rats
Wistar
Triglycerides
tissu adipeux brun
Glucose Tolerance Test
medicine.disease
type ii diabetes
Rats
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
Hyperglycemia
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
Insulin Resistance
Energy Metabolism
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Zdroj: Diabetes
Diabetes, American Diabetes Association, 2017, 66 (3), pp.627-639. ⟨10.2337/db16-0956⟩
Diabetes, 2017, 66 (3), pp.627-639. ⟨10.2337/db16-0956⟩
ISSN: 1939-327X
0012-1797
DOI: 10.2337/db16-0956⟩
Popis: E.-Z.A. was supported by the EU FP7 project DIABAT (HEALTH-F2-2011-278373). M.P. holds the Canada Research Chair in Diabetes and Metabolism. E.V.O. was supported by INSERM, Universite Cote d'Azur, Conseil Regional PACA, Conseil General des Alpes-Maritimes, Aviesan/AstraZeneca (Diabetes and the vessel wall injury program), the Agence Nationale de la Recherche (ANR) through ANR-RPV12004AAA (DIAMIR) "Investments for the Future" LABEX SIGNALIFE ANR-11-LABX-0028-01, and the European Foundation for the Study of Diabetes (EFSD/Lilly, European Diabetes Research Program). E.V.O. team members are affiliated with the FHU OncoAge (http://www.oncoage.org/); Epidemiological and animal studies show that deleterious maternal environments predispose aging offspring to metabolic disorders and type 2 diabetes. Young progeny in a rat model of maternal low protein diet (LP) is normoglycemic despite collapsed insulin secretion. However, without further worsening of the insulin secretion defect glucose homeostasis deteriorates in aging LP descendants. Here we report that normoglycemic and insulinopenic 3-month-old LP progeny shows increased body temperature and energy dissipation in association with enhanced brown adipose tissue (BAT) activity. In addition, it is protected against a cold challenge and high fat diet (HFD)-induced obesity with associated insulin resistance and hyperglycemia. Surgical BAT ablation in 3-month-old LP offspring normalizes body temperature and causes postprandial hyperglycemia. At 10 months BAT activity declines in LP progeny with appearance of reduced protection to HFD-induced obesity; at 18 months LP progeny displays a BAT activity comparable to control offspring and insulin resistance and hyperglycemia occur. Together our findings identify BAT as a decisive physiological determinant of the onset of metabolic dysregulation in offspring predisposed to altered beta cell function and hyperglycemia, and place it as a critical regulator of fetal programming of adult metabolic disease
Databáze: OpenAIRE
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