General maternal medication use, folic acid, the MDR1 C3435T polymorphism, and the risk of a child with a congenital heart defect

Autor: Régine P.M. Steegers-Theunissen, Ilse P. van der Heiden, Cornelia M. van Duyn, Ron H.N. van Schaik, Zobia Younes, Eric A.P. Steegers, Sylvia A. Obermann-Borst, Aaron Isaacs
Přispěvatelé: Obstetrics & Gynecology, Epidemiology, Clinical Chemistry
Rok vydání: 2011
Předmět:
Vitamin
Adult
Heart Defects
Congenital
Pediatrics
medicine.medical_specialty
ATP Binding Cassette Transporter
Subfamily B
Drug-Related Side Effects and Adverse Reactions
Offspring
ATP Binding Cassette Transporter
Member 1/genetics
chemistry.chemical_compound
Folic Acid
Genetic
Pregnancy
Risk Factors
Congenital/etiology
Surveys and Questionnaires
Genotype
medicine
Prenatal Exposure Delayed Effects/etiology
Humans
Genetic Predisposition to Disease
Heart Defects
Congenital/etiology
ATP Binding Cassette Transporter
Subfamily B
Member 1
Risk factor
Polymorphism
Heart Defects
Polymorphism
Genetic
Vitamin B Complex/therapeutic use
business.industry
ATP Binding Cassette Transporter
Subfamily B
Member 1/genetics
Obstetrics and Gynecology
Infant
Odds ratio
medicine.disease
Confidence interval
chemistry
El Niño
Subfamily B
Maternal Exposure
Prenatal Exposure Delayed Effects
Vitamin B Complex
Female
business
Folic Acid/therapeutic use
Zdroj: American Journal of Obstetrics and Gynecology, 204(3). Mosby Inc.
American Journal of Obstetrics and Gynecology, 204(3), 236.e1-8. MOSBY-ELSEVIER
ISSN: 0002-9378
Popis: OBJECTIVE: We sought to investigate maternal and child functional MDR1 C3435T polymorphism, periconception medication, folic acid use, and the risk of a congenital heart defect (CHD) in the offspring.STUDY DESIGN: MDR1 3435C>T genotyping was performed in 283 case triads (mother, father, child) and 308 control triads. Information on periconception medication and folic acid use was obtained through questionnaires.RESULTS: Mothers with MDR1 3435CT/TT genotype and using medication showed a significant association with the risk of a child with CHD (odds ratio [OR], 2.4; 95% confidence interval [CI], 1.3-4.3) compared to mothers with MDR1 3435CC genotype not using medication. This risk increased without folic acid use (OR, 2.8; 95% CI, 1.2-6.4), and decreased in folic acid users (OR, 1.7; 95% CI, 0.8-3.7). Children carrying the MDR1 3435CT/TT genotype and periconceptionally exposed to medication without folic acid did not show significant risks.CONCLUSION: Mothers carrying the MDR1 3435T allele, using medication without folic acid, are at nearly 3-fold increased risk for CHD in the offspring.
Databáze: OpenAIRE
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