Lamotrigine in Rett syndrome
| Autor: | F J Hansen, P Uldall, B Tonnby |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Drug
Adult medicine.medical_specialty medicine.medical_treatment media_common.quotation_subject Rett syndrome Lamotrigine Epilepsy Degenerative disease Glutamates Internal medicine medicine Rett Syndrome Humans Child media_common Cerebrospinal Fluid Chemotherapy business.industry Triazines Glutamate receptor General Medicine medicine.disease Anticonvulsant Endocrinology Treatment Outcome Child Preschool Pediatrics Perinatology and Child Health Anticonvulsants Female Neurology (clinical) business medicine.drug |
| Zdroj: | Neuropediatrics. 24(6) |
| ISSN: | 0174-304X |
| Popis: | An elevated CSF glutamate level has recently been reported in Rett syndrome. Because the anticonvulsant effect of Lamotrigine is probably due to inhibition of glutamate release, this drug was given as an add-on drug to 4 girls with Rett syndrome. All patients responded with a seizure reduction of 50% or more and an improved well-being. A controlled study at the early stages of the syndrome could be interesting. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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