Oesophageal endoscopic ultrasound with fine needle aspiration improves and simplifies the staging of lung cancer
| Autor: | Albert J. H. Suurmeijer, Hendricus Groen, Wendy J. Post, Alphons H. H. Bongaerts, Jan Pruim, H M van Dullemen, Hjm Groen, Theo J. Klinkenberg, J W G van Putten, Henk Kramer |
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| Přispěvatelé: | Faculteit Medische Wetenschappen/UMCG, Center for Liver, Digestive and Metabolic Diseases (CLDM), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Damage and Repair in Cancer Development and Cancer Treatment (DARE) |
| Jazyk: | angličtina |
| Rok vydání: | 2004 |
| Předmět: |
Pulmonary and Respiratory Medicine
Endoscopic ultrasound medicine.medical_specialty Lung Neoplasms Cost effectiveness Malignancy DIAGNOSIS Endosonography Mediastinoscopy POSITRON-EMISSION-TOMOGRAPHY ULTRASONOGRAPHY medicine Humans skin and connective tissue diseases Lung cancer Lung Ultrasonography Interventional EUS Neoplasm Staging medicine.diagnostic_test business.industry Lung Cancer Biopsy Needle medicine.disease digestive system diseases body regions surgical procedures operative Fine-needle aspiration PET METASTASES Cardiothoracic surgery Radiology Lung cancer staging business CT |
| Zdroj: | Thorax, 59(7), 596-601. BMJ PUBLISHING GROUP |
| ISSN: | 1468-3296 0040-6376 |
| Popis: | Background: Positron emission tomography ( PET) is accurate for mediastinal staging of lung cancer but has a moderate positive predictive value, necessitating pathological verification. Endoscopic ultrasonography with fine needle aspiration (EUS-FNA) is a technique for tissue verification of mediastinal and upper retroperitoneal abnormalities. The use of EUS-FNA may decrease the number of surgical procedures and thereby staging costs.Methods: EUS-FNA was used prospectively for the cytological assessment of mediastinal and/or upper retroperitoneal PET hot spots in patients with suspected lung cancer. Only if EUS-FNA was positive for malignancy was subsequent mediastinoscopy or exploratory thoracotomy cancelled. The cost effectiveness of EUS-FNA was determined.Results: Of 488 consecutive patients with suspected lung cancer, 81 were enrolled with mediastinal and/or upper retroperitoneal PET hot spots. EUS-FNA was positive in 50 (62%) patients, negative in six, and inconclusive in 25. Of the 31 negative or inconclusive patients, 26 underwent surgical staging ( resulting in 14 patients with and 12 without mediastinal malignancy), while five patients had mediastinal metastases during follow up. No EUS-FNA related morbidity or mortality was encountered. The accuracy of the decision to proceed to surgery ( or not) on the basis of EUS-FNA was 77% (95% CI 68 to 86). EUS-FNA detected more mediastinal abnormalities than PET except for the upper mediastinal region. Addition of EUS-FNA to conventional lung cancer staging reduced staging costs by 40% per patient, mainly due to a decrease in surgical staging procedures.Conclusion: EUS-FNA can replace more than half of the surgical staging procedures in lung cancer patients with mediastinal and/or upper retroperitoneal PET hot spots, thereby saving 40% of staging costs. |
| Databáze: | OpenAIRE |
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