Indirect fluorescent-antibody technique for serological diagnosis of La Crosse (California) virus infections
| Autor: | D Nelson, Wayne H. Thompson, J T McPherson, J Casals, K L Brown, C B Gundersen, Barry J. Beaty |
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| Jazyk: | angličtina |
| Rok vydání: | 1982 |
| Předmět: |
Microbiology (medical)
Male Hemagglutination Inhibition Tests La Crosse virus Hemagglutination animal diseases Fluorescent Antibody Technique chemical and pharmacologic phenomena Biology medicine.disease_cause Serology Encephalitis California Neutralization Tests parasitic diseases medicine Humans Serologic Tests California encephalitis virus Child Hemagglutination assay Encephalitis Arbovirus virus diseases bacterial infections and mycoses Virology Titer Immunoglobulin M Child Preschool biology.protein Female Research Article |
| Popis: | A clinically relevant indirect fluorescent-antibody technique (IFA) was developed for the serological diagnosis of La Crosse virus infections. The IFA (67%) was as sensitive as the hemagglutination inhibition (58%) and neutralization (58%) tests in the detection of antibodies in acute-phase specimens. Immunoglobulin M antibodies were detected by the IFA test in 48% (11 of 23) of these specimens. Diagnostically significant increases in IFA titer were detected in 86% (19 of 22) of the paired samples. Antibodies were detectable in some patients 7 years after infection; however, the IFA test was not as sensitive as the other two tests in the detection of previous infections. |
| Databáze: | OpenAIRE |
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