Predictive and Prognostic Value of Ascitic Fluid Mannose Binding Lectin in Patients with Spontaneous Bacterial Peritonitis
| Autor: | Amal Ahmed Mohamed, Mahmoud Elkadeem, Naglaa El-Toukhy, Dalia A. El-damasy, Rania Abdelmonem Khattab, Sherief Abd-Elsalam, Ahmed Sabry, Abeer Ahmed, Mohamed Abdel-Hamid |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Immunology Peritonitis Mannose-Binding Lectin Gastroenterology chemistry.chemical_compound Spontaneous bacterial peritonitis Model for End-Stage Liver Disease Internal medicine Ascites medicine Ascitic Fluid Humans Immunology and Allergy Mannan-binding lectin Pharmacology Creatinine business.industry Albumin General Medicine Middle Aged medicine.disease MBL deficiency chemistry Female medicine.symptom business |
| Zdroj: | Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry. 20:196-200 |
| ISSN: | 1871-5230 |
| Popis: | Background/Aim: Spontaneous bacterial peritonitis is a common bacterial infection of ascitic fluid mainly in ascites due to liver cirrhosis. Mannose-binding lectin (MBL) can activate phagocytosis and the complement system. Spontaneous bacterial peritonitis was detected to be higher in MBL deficiency. This study aimed to assess ascitic fluid MBL in liver cirrhosis and spontaneous bacterial peritonitis. Methods: Ninety patients with cirrhotic ascites were included. Forty five of them had SBP. Child-Pugh score, Model for End Stage Liver Disease (MELD) and its update (uMELD) scores were used to assess severity of liver cirrhosis. Ascitic fluid samples were obtained for differentiation of leucocytic count, estimation of albumin, protein, glucose, and serumascitic albumin gradient. Ascitic fluid levels of MBL were measured for all patients. SBP was documented if polymorphonuclear leucocytic count ≥250/mm in ascitic fluid. Results: Ascitic fluid MBL level was significantly lower in patients with SBP. MBL had a significant negative correlation with ascitic total leukocytic count (TLC), also with serum creatinine, bilirubin, PT, INR and MELD score among SBP patients. However, it had a significant positive correlation with ascitic protein and with platelets. According to multivariate analysis; fever, TLC, platelets, creatinine, MBL, glucose and polymorphs were independent predictors for SBP development. Conclusion: Ascitic fluid MBL could be a good predictive and prognostic marker in patients with cirrhosis and spontaneous bacterial peritonitis. |
| Databáze: | OpenAIRE |
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