Hemorrhagic regression of melanoma metastases during therapeutic vaccination: a report of three cases
| Autor: | Arlette De Coninck, Carlo Heirman, Annieta Goossens, An M. T. Van Nuffel, L. Pierret, Jurgen Corthals, Nicolas van Baren, G Verfaillie, Diane Roseeuw, Bart Neyns, Ellen Degreef, Kris Thielemans, Truus Roelandt, Aude Bonehill, Ivan Van Riet |
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| Přispěvatelé: | Physiology, Skin function and permeability, Hematology, Pathological Anatomy, Laboratory of Molecular and Medical Oncology |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Skin Neoplasms Central nervous system Hemorrhage Dermatology Cancer Vaccines Metastasis Central Nervous System Neoplasms Hematoma melanoma peptide vaccine Humans dendritic cell vaccine metastasis Medicine Spontaneous hemorrhage hemmorhagic Neovascularization Pathologic business.industry Melanoma Vaccination Middle Aged medicine.disease Clinical trial medicine.anatomical_structure Oncology Disease Progression Female business Intracranial Hemorrhages Brain metastasis |
| Zdroj: | Vrije Universiteit Brussel |
| ISSN: | 0960-8931 |
| Popis: | Melanoma metastases are characterized by pronounced neo-angiogenesis and spontaneous bleeding frequently occurring within central nervous system metastases. Clinically apparent spontaneous hemorrhage within subcutaneous melanoma metastases, however, is a rare event that coincides with progression of such metastases. We report, to our knowledge the first observation, on regression of subcutaneous metastases with hemorrhage of the overlying skin in three patients with stage IV melanoma who participated in clinical trials on therapeutic vaccination. In two patients, loss of arterial flow on Doppler ultrasound imaging was documented in the metastasis at the time of hematoma formation. One patient suffered from an intracranial hemorrhage in a subcentimetric brain metastasis coincident with the hemorrhagic regression of some of his skin metastases. |
| Databáze: | OpenAIRE |
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