Intra-operative erythropoietin during laparoscopic partial nephrectomy is not renoprotective
| Autor: | Samuel K. Park, Saad A. Mir, Yung K. Tan, Sara L. Best, Ephrem O. Olweny, Jeffrey A. Cadeddu, Cenk Gurbuz, Stephen Faddegon |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Nephrology medicine.medical_specialty Urology medicine.medical_treatment Renal function Kidney Nephrectomy Cohort Studies Intraoperative Period Internal medicine Occlusion medicine Humans Minimally Invasive Surgical Procedures Postoperative Period Warm Ischemia Renal Insufficiency Chronic Erythropoietin Aged Retrospective Studies Dose-Response Relationship Drug business.industry Retrospective cohort study Perioperative Middle Aged Surgery Treatment Outcome medicine.anatomical_structure Creatinine Reperfusion Injury Female Laparoscopy business Follow-Up Studies Glomerular Filtration Rate medicine.drug |
| Zdroj: | World Journal of Urology. 30:519-524 |
| ISSN: | 1433-8726 0724-4983 |
| DOI: | 10.1007/s00345-011-0760-6 |
| Popis: | In pre-clinical studies, acute erythropoietin (EPO) administration has been shown to mitigate the deleterious effects of ischemia/reperfusion injury. We reviewed our clinical experience with intraoperative EPO administration as a potential renoprotective agent during laparoscopic partial nephrectomy (LPN). Patients who underwent LPN at our institution between August 2008 and March 2010 received 500 IU/kg EPO 30 min prior to hilar occlusion. Those who underwent LPN between August 2006 and July 2008 without receiving EPO were selected as controls. Demographic, clinical, perioperative, and estimated glomerular filtration rate (eGFR) data were compared for the cohorts preoperatively, and during short-term ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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