Synbiotic Supplementation Improves Obesity Index and Metabolic Biomarkers in Thai Obese Adults: A Randomized Clinical Trial
| Autor: | Suchanat Khongtan, Nanticha Khampithum, Sartjin Peerajan, Subramanian Thangaleela, Periyanaina Kesika, Sasithorn Sirilun, Chaiyavat Chaiyasut, Akkarach Bumrungpert, Bhagavathi Sundaram Sivamaruthi, Phakkharawat Sittiprapaporn, Khontaros Chaiyasut |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
obesity Health (social science) Bifidobacterium longum Synbiotics ved/biology.organism_classification_rank.species Physiology 030209 endocrinology & metabolism Plant Science Type 2 diabetes TP1-1185 Overweight Health Professions (miscellaneous) Microbiology Article 03 medical and health sciences 0302 clinical medicine medicine fructooligosaccharide synbiotics Bifidobacterium Bifidobacterium breve biology inulin business.industry ved/biology Chemical technology medicine.disease biology.organism_classification Obesity Lactobacillus 030104 developmental biology medicine.symptom business Dyslipidemia Food Science |
| Zdroj: | Foods, Vol 10, Iss 1580, p 1580 (2021) Foods Volume 10 Issue 7 |
| ISSN: | 2304-8158 |
| Popis: | The cluster of metabolic disorders includes obesity, dyslipidemia, hypertension, and glucose intolerance, increasing the risk of developing cardiovascular diseases and type 2 diabetes. Evolving proofs suggest an essential role of microbiota in human health and disease, including digestion, energy and glucose metabolism, immunomodulation, and brain function. The frequency of overweight is increasing, and the main causes for this are highly processed foods and less active lifestyles. Research is underway to unravel the probable relationship between obesity and intestinal microbiota. Here, we propose a method to understand and elucidate the synergistic function of prebiotics and probiotics in treating obesity. The biomarkers of obesity, such as cholesterol, gut permeability, oxidative stress, bacterial toxins, cytokines, and short-chain fatty acids, were analyzed in Thai obese individuals after being supplemented with a synbiotic preparation containing Lactobacillus paracasei, Bifidobacterium longum, Bifidobacterium breve, inulin, and fructooligosaccharide. The results reveal that the supplementation of synbiotics significantly altered the obesity-associated biomarkers in an appositive way. Further studies are warranted to use synbiotics as an adjuvant therapy for the management of obesity-related health issues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|