Clinical Characteristics and Outcomes of COVID-19 Patients with Overweight and Obesity: Turkish Nationwide Cohort Study (TurCObesity)
| Autor: | Murat Caglayan, Derun Taner Ertugrul, Alper Sonmez, Rifat Emral, Cem Haymana, Osman Celik, Ilhan Satman, Ibrahim Demirci, Serpil Salman, Erman Cakal, Ilker Tasci, Ibrahim Sahin, Mustafa Sahin, Naim Ata, Aysegul Atmaca, Ugur Unluturk, Selcuk Dagdelen, Tevfik Demir |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Turkey Endocrinology Diabetes and Metabolism medicine.medical_treatment MEDLINE Overweight Disease-Free Survival Endocrinology Risk Factors Internal medicine Internal Medicine medicine Humans Intubation Obesity Retrospective Studies Mechanical ventilation SARS-CoV-2 business.industry COVID-19 Retrospective cohort study General Medicine Middle Aged medicine.disease Survival Rate Female medicine.symptom business Kidney disease Cohort study |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 130:115-124 |
| ISSN: | 1439-3646 0947-7349 |
| Popis: | Purpose While obesity is related to more severe outcomes of coronavirus disease 2019 (COVID-19), factors leading to poor prognosis still remain unclear. The present study evaluated the outcomes of COVID-19 patients who were overweight or obese and variables associated with severe disease in a large group of consecutive cases. Methods A nationwide retrospective cohort study was performed using the Turkish National Healthcare Database. Demographic characteristics, laboratory tests, comorbidities, and medications of patients registered between March 11 and May 30, 2020, were recorded. Results A total of 14, 625 patients (median age:42, IQR:26 years; female 57.4%) with normal weight (34.7%), overweight (35.6%), and obesity (29.7%) were included. Hospitalization, ICU admission, intubation/mechanical ventilation, pulmonary involvement, and mortality were significantly higher in patients who were overweight or obese. In adjusted analyses, both overweight (OR, 95% CI: 1.82, 1.04–3.21; p=0.037) and obesity (OR, 95% CI: 2.69, 1.02–1.05; p Conclusions COVID-19 patients who were overweight or obese were more likely to have adverse outcomes but only obesity was a predictor of mortality. Such patients should receive urgent medical attention and active management, especially the elderly, men, and people with chronic kidney disease. |
| Databáze: | OpenAIRE |
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